les virus respiratoires sont nombreux; on estime que l'enfant, dans son enfance (jusqu'à 8 ans environ) fait la rencontre d'environ 200 virus). Les virus les plus fréquents sont au nombre de 8. Lorsqu'ils infectent un enfant, ils restent dans l'épithélium respiratoire environ 1 an, et l'un parmi eux (le RSV ou respiratoire syncitial virus) peut rester niché des années dans la moëlle osseuse. Ainsi, l'enfant peut rester fragile de 12 mois à plusieurs années, présentant 1X/6 un asthme bronchique de l'enfant.
la récente propagande de protéger les nourrissons contre " la bronchiolite à RSV" (et pas contre les 7 autres virus responsables d'une bronchiolite) est scientifiquement absusive: le schéma et la dose proposée ne sont pas adéquats, et il fautdra encore revoir celles-ci.
Par contre les inconvénients existent et son repris dans l'article scientifique suivant:
Respiratory infections with respiratory syncytial virus (RSV) account for an important part of hospital admissions for acute respiratory infections. Nirsevimab has been developed to reduce the hospital burden of RSV infections. Compared with the product previously used, it has a stronger binding capacity to RSV F protein and a high affinity for FcRn (neonatal receptor for the Fc fragment of IgG), which extends its lifespan. Nirsevimab has been shown to be highly effective in reducing hospitalization rates of RSV infections but a large or unknown number of treated subjects have been excluded in clinical and post-marketing studies. However, analysis of these studies cannot exclude that, in rare cases, nirsevimab facilitates and worsens RSV infection (or other respiratory infections). This could be attributable to antibody-dependent enhancement (ADE) which has been observed with RSV F protein antibodies in inactivated vaccine trials. This risk has been incompletely assessed in pre-clinical and clinical trials (incomplete exploration of nirsevimab effector functions and pharmacokinetics). ADE by disruption of the immune system (not studied and due to FcRn binding) could explain why there is no reduction in all-cause hospital admissions in treated age groups. Given the high price of nirsevimab, the cost-effectiveness of mass immunization campaigns may therefore be debated from an economic as well as a scientific point of view.
